Organos can provide analysis of action potential and calcium transient dynamic features in our cardiac MPS to predict drug-induced arrhythmia.
Organos uses a proprietary in silico framework to computationally invert these measurements into mechanisms of action, and provides estimated IC50 values of ion channel binding for hERG, Peak Nav1.5, Late Nav 1.5, and Cav 1.2. Our computational framework can also be used to project the results obtained in the MPS onto mature human phenotypes, as well as a canine cellular model to predict expected differential effects and dose dynamics across species and in adult native cells.
Muscle Twitch and Coupled EP-Twitch Dynamics
Through the use of high resolution imaging of the beating cardiac tissue, changes in muscle twitch dynamics can be calculated in terms of length and magnitude of twitch strains. Drug-induced changes in the upstroke and relaxation dynamics, as well as changes in force generation compared to calcium transient can also be determined.
Due to the stability of the cardiac MPS, both EP and twitch studies can be done under long-term (>24 hour) compound exposure to test for chronic exposure liability and to mimic clinical exposure. Long-term analyses can be performed in accordance with client's needs.